Angela, I am aware of this problem, also upcoming versions of Chrome have some problems that are resolved in the recent beta versions. I am hoping to release the next official version soon.

Guest101, finally I was able to reproduce the slowdown. It actually affects everything and not just Adobe Reader X. For example Start.exe takes more time to launch a program, and Internet Explorer starts slower. But of course Adobe Reader X sees the most pronounced effect with a huge delay.

The problem is SpyBot adds a TON of registry keys below this registry key,
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Internet Settings\ZoneMap

I think I will be able to develop a solution to this problem.

Yes, you're right. After using the "undo" function many programs start faster. It's great news that there will be a solution possible.

Thank you for reproducing the problem and your great support.

Thank you for this information.
i or we ever now that SD causes a lot of interference with other security programs
but this seems to be the icing of all its (censored).

Please check if version 3.51.09 fixes this problem.

The new version is a big improvement. Not as quick as an unsandboxed Reader, but much faster like before. The delay is reduced to about 10 seconds, which is an acceptable value. Thank you very much.

Excellent, great to hear this problem is fixed and thanks for sticking with this until we figured it out. Also while addressing this issue, I was able to make Start.exe start slightly faster, so benefits all around.